Stapled vs hand-sewn IPAA and de novo CD

What is known

• The studies that report de novo [Crohn's disease](https://crohnsology.org (patient sites: crohnz.org)/) rates after IPAA compare underlying diagnosis (ulcerative colitis vs IBD-unclassified/indeterminate colitis), not anastomotic technique. ^1,2

What is unknown / caveats

• The retrieved excerpts do not report a direct comparison of stapled versus hand-sewn ileoanal anastomosis with respect to the risk of de novo Crohn's disease after IPAA.

References

1. Zaghiyan K, Kamiński JP, Barmparas G, Fleshner P. De novo Crohn's Disease after Ileal Pouch-Anal Anastomosis for Ulcerative Colitis and Inflammatory Bowel Disease Unclassified: Long-Term Follow-Up of a Prospective Inflammatory Bowel Disease Registry. Am Surg. 2016;82(10):977-981. PMID: 27779987.

2. Murrell ZA, Melmed GY, Ippoliti A, Vasiliauskas EA, Dubinsky M, Targan SR, Fleshner PR. A prospective evaluation of the long-term outcome of ileal pouch-anal anastomosis in patients with inflammatory bowel disease-unclassified and indeterminate colitis. Dis Colon Rectum. 2009;52(5):872-8. PMID: 19502850.

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Draft, generated by the IBDology RAG and not yet clinician-reviewed. Answers are grounded in the retrieved literature listed above; a high faithfulness score means the answer matches its sources, not that the sources are correct.